Click through our range of case studies below to find out how Aspherix® and CFDEM®coupling is applied to effectively support simulations in various pharmaceutical industries.
DEM simulations of rotary tablet press in collaboration with Alkermes Inc.*
Effect of paddle and turret velocities (from 20 to 80 RPM) on:
*Li, Zihao, et al. “Particle Scale Insights into a KG-Pharma RoTab Tablet Press Feed-Frame System Using the Discrete Element Method (DEM) Modeling.” Processes 11.1 (2023): 119.
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Simulation of commercial scale tablet press feed system with a coupled CFD-DEM model.
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This video shows a full-coupled CFD-DEM simulation of a fluidized bed granulation process. A liquid-solid mixture is sprayed into the granulator (see droplets in magenta) from a nozzle. The liquid and solid species are deposited onto the carrier particles and, partially, onto the granulator walls. The product quality (between 0 to 1) measures the coating/granulation level of the carrier particles. Finally, the temperature field changes dynamically due to the heating from the fluidization air and the cooling due to the liquid evaporation.
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Twin-screw extruders (TSEs) are widely used for processing polymers, chemicals and foodstuff.
Development of a 1D-3D model for polymer extrusion in TSE (collaboration with Novartis*)
The 3D part consists of DEM simulations of representative volume elements (RVEs)
The 1D part is a low-order model bridging the solution between the RVEs
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The animation shows the simulation of the release of API from coated particles in a dry powder inhaler. On the left side we see the API concentration in the air, on the right side the coating on the particles.
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Simulation of paste extrusion where the Edinburgh model is used to model cohesion.
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The animation shows the flow of 5 micron sized evaporating droplets flowing through the nasal airways during a respiration cycle. The air flow information is pre-calculated using CFD and the transient flow field is imported to Aspherix®.
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This simulation shows a roller compaction process, where a lactose powder is compacted into a ribbon by two counter-rotating rollers. The material is grabbed by the cylinders due to particle/wall friction and transported into the compaction zone, where the ribbon is formed. Roller compaction is a typical dry granulation step and the produced ribbon is generally comminuted into granules with the desired size.
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